Yu Han received his B.S. in Chemistry from the School of Chemistry and Chemical Engineering at Nanjing University in 2016, where he worked under the supervision of Professor Huan Wang. In 2021, he earned his Ph.D. in Chemical Biology from the College of Chemistry and Molecular Engineering at Peking University, under the guidance of Professor Peng Chen. His doctoral dissertation was recognized as an Excellent Doctoral Dissertation of Peking University. He then conducted postdoctoral research at the Academy for Advanced Interdisciplinary Studies at Peking University from 2022 to 2025. In 2026, he joined the State Key Laboratory of Microbial Technology at Shandong University.
Research Interests
Protein Engineering and Chemical Biology
Biocatalysis and Synthetic Biology
Major Funding
China National Postdoctoral Program for Innovative Talents, BX20220004
Publications
1. Yicong Ma#, Jianfei Jiang#, and Yu Han* Degrade to Display: Coupling Checkpoint Degradation with Exogenous Antigen Presentation to Boost Antitumor Immunity. ACS Chem. Biol. 2026, 21, 909–912.
2. Yu Han#, Yicong Ma#, Miao Pei#, Shenyi Yin, Jiahao Wang, Liyu Guo, Yike Fang, Weiming Guo, Chunjiang Deng, Su Zhao, Xueyin Lu, Jianzhong Jeff Xi*, Heng Zhang*, and Peng R. Chen* Intratumoural vaccination via checkpoint degradation-coupled antigen presentation. Nature 2026, 650, 736–747.
3. Yu Han#, Zhenlin Yang#, Hengrui Hu#, Heng Zhang, Long Chen, Kexin Li, Linghao Kong, Qianran Wang, Bo Liu, Manli Wang*, Jian Lin*, and Peng R. Chen* Covalently Engineered Protein Minibinders with Enhanced Neutralization Efficacy against Escaping SARS-CoV-2 Variants. J. Am. Chem. Soc. 2022, 144, 5702–5707.
4. Heng Zhang#, Yu Han#, Yuanfan Yang, Feng Lin, Kexin Li, Linghao Kong, Hongxiang Liu, Yongjun Dang, Jian Lin*, and Peng R. Chen* Covalently Engineered Nanobody Chimeras for Targeted Membrane Protein Degradation. J. Am. Chem. Soc. 2021, 143, 16377−16382. (Highly Cited Paper)
5. Qian-Fang Meng#, Yu Han#, Yu Liu#, Pan Pan#, Rong-Chang Chen, Heng Zhang*, and Lang Rao* Antiviral covalent ACE2 vesicle spray, Cell Biomater. 2025, 1, 100017.
6. Weiming Guo#, Yuan Liu#, Yu Han#, Huan Tang, Xinyuan Fan, Chu Wang*, and Peng R. Chen* Amplifiable protein identification via residue-resolved barcoding and composition code counting, Natl. Sci. Rev. 2024, 11, nwae183.
7. Kexin Li#, Xiao Xie#, Rui Gao#, Zhaoming Chen, Mingdong Yang, Zhihui Wen, Yicheng Weng, Xinyuan Fan, Gong Zhang, Lu Liu, Xiangmei Zeng, Yu Han, Mengrui Cao, Xin Wang, Jiaofeng Li, Zhenlin Yang, Tingting Li, and Peng R. Chen*. Spatiotemporal protein interactome profiling through condensation-enhanced photocrosslinking. Nat. Chem. 2024, 17, 111–123.
8. Hongxiang Liu, Zhijiang Fu, Yu Han, Yike Fang, Weijun Shen, Zhicheng Chen, Rongfeng Zhu, Heng Zhang*, and Peng R. Chen*. Conditionally Activatable Chimeras for Tumor-Specific Membrane Protein Degradation. J. Am. Chem. Soc. 2024, 146, 32933–32941.
9. Fangfei Qin#, Boyuan Li#, Hui Wang, Sihui Ma, Jiaofeng Li, Shanglin Liu, Linghao Kong, Huangtao Zheng, Rongfeng Zhu, Yu Han, Mingdong Yang, Kai Li, Xiong Ji*, Peng R Chen*. Linking chromatin acylation mark-defined proteome and genome in living cells. Cell 2023, 186, 1066-1085.e36.
10. Rongfeng Zhu#, Gong Zhang#, Miao Jing, Yu Han, Jiaofeng Li, Jingyi Zhao, Yulong Li, and Peng R Chen*. Genetically encoded formaldehyde sensors inspired by a protein intra-helical crosslinking reaction. Nat. Commun. 2021, 12, 581.
11. Jinjun Gao#, Fan Yang#, Jinteng Che, Yu Han, Yankun Wang, Nan Chen, Daniel W. Bak, Shuchang Lai, Xiao Xie, Eranthie Weerapana, and Chu Wang* Selenium-Encoded Isotopic Signature Targeted Profiling. ACS Cent. Sci. 2018, 4, 960–970.