Research Interests
Enzymology and Enzyme Engineering of Microbial Peroxygenases
Biocatalysis and Synthetic Biology
Education & Working Experience
07/2025-now Associate Professor, Shandong University
07/2021-07/2025 Postdoctoral Researcher, Shandong University
09/2016-06/2021 Doctor of Science, University of Chinese Academy of Sciences
09/2012-06/2016 Bachelor of Technology, Nanchang University
Major Funding
National Natural Science Foundation of China, 32300021
Marie Sklodowska-Curie Postdoctoral Fellowships, 101201903
China Postdoctoral Science Foundation, 2022M710080
Postdoctoral Innovation Project of Shandong Province, SDCX-ZG-202201005
Shandong Provincial Natural Science Foundation, ZR2023QC021
Qingdao Natural Science Foundation, 23-2-1-25-zyyd-jch
Publications
1. Jiang, Y.#, Gong, P.#, Li, Z.#, Li, Z., Li, Y., Wang, B., Huang, H.*, Peng, W.*, Gao, X.*, Li, S.* Unexpected activities of CYP152 peroxygenases towards non-carboxylic substrates reveal novel substrate recognition mechanism and catalytic versatility. Angew. Chem. Int. Ed. 2025, 64, e202506614. (IF = 16.9)
2. Jiang, Y.#, Li, P.#, Li, Z., Zhang, B.*, Li, S.* Photoenzymatic synthesis of 1-alkenes and hydroxyl fatty acids by cascading a COF photocatalyst and P450 peroxygenases. Sci. Bull. 2024, 69, 3350-3354. (IF = 21.1)
3. Jiang, Y.#, Peng, W.#, Li, Z.#, You, C., Zhao, Y., Tang, D., Wang, B.*, Li, S.* Unexpected reactions of α,β-unsaturated fatty acids provide insight into the mechanisms of CYP152 peroxygenases. Angew. Chem. Int. Ed. 2021, 60, 24694-24701. (IF = 16.9)
4. Jiang, Y., Li, Z., Zheng, S., Xu, H., Zhou, Y. J., Gao, Z., Meng, C.*, and Li, S.* Establishing an enzyme cascade for one-pot production of α-olefins from low-cost triglycerides and oils without exogenous H2O2 addition. Biotechnol. Biofuels 2020, 13, 52. (IF = 6.1)
5. Jiang, Y., Li, Z., Wang, C., Zhou, Y., Xu, H.*, and Li, S.* Biochemical characterization of three new α-olefin-producing P450 fatty acid decarboxylases with a halophilic property. Biotechnol. Biofuels 2019, 12, 79. (IF = 6.1)
6. Li, Z.#, Jiang, Y.#, Guengerich, F. P., Ma, L., Li, S., and Zhang, W.* Engineering cytochrome P450 enzyme systems for biomedical and biotechnological applications. J. Biol. Chem. 2020, 295, 833-849. (IF = 3.9)
7. Jiang, Y.#, Li, Z.#, Li, S.* Superoxide-mediated O2 activation drives radical cyclization in ergot alkaloid biosynthesis. Eng. Microbiol. 2025, 5, 100207. (Research Highlight)
8. Jiang, Y., Li, S.* P450 fatty acid decarboxylase. Methods Enzymol. 2023, 693: 339-374. (Book Chapter)
9. Jiang, Y., Li, S.* The catalytic function and application of cytochrome P450 enzymes in biosynthesis and organic synthesis. Chin. J. Org. Chem. 2018, 38, 2307-2323.
10. Li, Z.#, Zhang, L.#, Kang, X.#, Jiang, Y., Du, J., Zhang, X., Meng, L., Wu, Q., Du, L., Li, X., Hu, Y., Xie, Z., Jiang, X., Tang, Y., Wu, R.*, Guo, R.*, Li, S.* Molecular insights into the catalytic promiscuity of a bacterial diterpene synthase. Nat. Commun. 2023, 14, 4001.
11. Li, Z., Jiang, Y., Zhang, X., Chang, Y., Li, S., Zhang, X., Zheng, S., Geng, C., Meng, P., Ma, L., Yang, Y., Gao, Z., Tang, Y., Li, S.* Fragrant venezuelaenes A and B with a 5−5−6−7 tetracyclic skeleton: discovery, biosynthesis, and mechanisms of central catalysts. ACS Catal. 2020, 10, 5846-5851.
12. Xu, H., Liang, W., Ning, L., Jiang, Y., Yang, W., Wang, C., Qi, F., Ma, L., Du, L., Fourage, L., Zhou, Y. J. and Li, S.* Directed evolution of P450 fatty acid decarboxylases via high-throughput screening towards improved catalytic activity. ChemCatChem 2019,12, 80-84.