Hui Chen, Ph.D., Professor, at Shandong University. He earned his B.En. in bioengineering from Ludong University of China (2007). From 2007 to 2010, he studied with Professor Xiangqun Xu at Zhejiang Sci-Tech university for his master’s degree. From 2010 to 2014, he pursued his Ph.D. degree under the supervision of Professor Lirong Yang at Zhejiang University. From 2014 to 2015, he worked at Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, as an assistant professor. From 2015 to 2018, he performed his postdoctoral research at Virginia Tech and the University of Minnesota, Twin City, consecutively. From 2018 to 2021, he continued his postdoctoral research in the Department of Chemistry, University of Utah, under the supervision of Professor Shelley D. Minteer. From 2021 to 2022, he was promoted and worked as a research assistant professor (faculty member) in the Department of Chemistry, University of Utah, USA. Since from 2022, he was recruited as a full Professor at Shandong University.
Education & Working Experience
2022 – Now Professor, Shandong University
2021 – 2022 Research Assistant Professor, University of Utah, Salt Lake City, Utah, USA
2018 – 2021 Postdoctoral associate, University of Utah, Salt Lake City, Utah, USA
2017 – 2018 Postdoctoral associate, University of Minnesota, St. Paul, Minnesota, USA
2015 – 2017 Postdoctoral associate, Virginia Tech, Blacksburg, Virginia, USA
2014 – 2015 Assistant Professor, Chinese Academy of Sciences
2010 – 2014 Ph.D., Biochemical Engineering, Zhejiang University
2007 – 2010 Master, Applied Chemistry, Zhejiang Sci-Tech University
2003 – 2007 Bachelor, Bioengineering, Ludong University
Research Interests
Bioelectrocatalysis and Bioelectrosynthesis
Biocatalysis and Biotransformation
Synthetic Biology
Major Funding
National Natural Science Fund for Excellent Young Scientists Fund Program (Overseas) (国家自然科学基金优秀青年基金海外项目)
Shandong Excellent Young Scientists Fund Program (Overseas) (山东省优秀青年科学基金海外项目)
Taishan Young Scholar of Shandong Province (山东省泰山学者青年专家计划)
National Natural Science Foundation of China, 21406250 (国家自然科学基金，青年基金)
Publications
First author articles
1. N. Samali Weliwatte,# Hui Chen,#* Tianhua Tang, and Shelley D. Minteer* Three-Stage Conversion of Chemically Inert n‑Heptane to α‑Hydrazino Aldehyde Based on Bioelectrocatalytic C−H Bond Oxyfunctionalization. ACS Catalysis, 2022, DOI: 10.1021/acscatal.2c04003. (Accepted, IF = 13.08)
2. Burnett, J.W.#, Chen, H.#, Li, J., Li, Y., Huang, S., Shi, J., McCue, A.J., Howe, R.F., Minteer, S.D.* and Wang, X* Supported Pt Enabled Proton-Driven NAD(P)+ Regeneration for Biocatalytic Oxidation. ACS Applied Materials & Interfaces, 2022, 14(18), 20943-20952. (IF = 10.38)
3. Chen, H., Tang, T., Malapit, C.A., Lee, Y.S., Prater, M.B., Weliwatte, N.S. and Minteer, S.D.* One-Pot Bioelectrocatalytic Conversion of Chemically Inert Hydrocarbons to Imines. Journal of American Chemical Society, 2022, 144 (9), 4047-4056. (Cover paper, IF = 16.38)
4. Chen, H.#; Lin, Y.#; Long, Y. T.; Minteer, S.* Ying, Y. L.* Nanopore-based measurement of the interaction of P450cam monooxygenase and putidaredoxin at single-molecule level. Faraday Discussions, 2022, 233, 295-302. (IF = 4.00)
5. Chen, H.#; Simoska, O.#; Lim, K.; Grattieri, M.; Yuan M.; Dong, F.; Lee, Y.; Beaver, K.; Weliwatte, S.; Gaffney, E.; Minteer, S. D.* Fundamentals, Applications, and Future Directions of Bioelectrocatalysis. Chemical Reviews, 2020, 120(23), 12903-12993. (ACS Editors’ choice article, IF = 71.42)
6. Chen, H.; Prater, M. B.; Cai, R.; Dong, F.; Chen, H.; Minteer, S. D.* Bioelectrocatalytic Conversion from N2 to Chiral Amino Acids in a H2/α-Keto Acid Enzymatic Fuel Cell. Journal of American Chemical Society, 2020, 142 (8), 4028-4036. (IF = 16.38)
7. Chen, H.; Dong, F.; Minteer, S. D.* The progress and outlook of bioelectrocatalysis for the production of chemicals, fuels and materials. Nature Catalysis, 2020, 3, 225-244. (IF = 40.71)
8. Chen, H., Cai, R., Patel, J., Dong, F.Y., Chen, H., Minteer, S.* Upgraded Bioelectrocatalytic N2 Fixation: From N2 to Chiral Amine Intermediates. Journal of American Chemical Society, 2019, 141 (12), 4963-4971. (IF = 16.38)
9. Chen, H.*, Kim, E.J., Wu, C.H., Sun, J. S., Adams, M. W., Zhang, Y. H. P.* Building a thermostable metabolon for highly efficient cofactor transportation and in vitro biohydrogen production at elevated temperature. ChemSusChem, 2018, 11 (18), 3120-3130. (Backcover paper, IF = 9.14)
10. Chen, H., Meng X., Li, S.Y.* The molecular basis of lipase stereoselectivity. Applied Microbiology and Biotechnology 7, 2018, 102 (8), 3487-3495. (IF = 5.56)
11. Chen, H., Huang, R., Zhang, Y. H. P.* (2017). Systematic comparison of co-expression of multiple recombinant thermophilic enzymes in Escherichia coli BL21 (DE3). Applied Microbiology and Biotechnology, 2017, 101(11), 4481-4493. (IF = 5.56)
12. Chen, H.#, Zhu, Z.G.#, Huang, R., Zhang, Y. H. P.* (2016). Coenzyme engineering of a hyperthermophilic 6-phosphogluconate dehydrogenase from NADP+ to NAD+ with its application to biobatteries. Scientific Reports, 2016, 6, 36311. (IF = 4.99)
13. Chen, H.; Wu, J. P.*; Yang, L. R.*, Xu G. Improving Pseudomonas alcaligenes lipase’s diastereopreference in hydrolysis of diastereomeric mixture of menthyl propionate by site-directed mutagenesis. Biotechnology and Bioprocess Engineering, 2014, 19(4), 592-604. (IF = 3.38)
14. Chen, H., Wu, J. P.*, Yang, L. R.*, Xu G. Characterization and structure basis of Pseudomonas alcaligenes lipase’s enantiopreference towards d,l-menthyl propionate. Journal of Molecular Catalysis B-Enzymatic, 2014, 102, 81-87.
15. Chen, H., Wu, J. P.*, Yang, L. R.*, Xu G. (2013). A combination of sit-directed mutagenesis and site-specific modification to improve diastereopreference of Pseudomonas alcaligenes lipase. Biochimica et Biophysica Acta, 2013, 1834, 2494-2501. (IF = 3.03)
16. Chen H.; Yan M.; Zhu J.; Xu X.* Enhancement of exo-polysaccharide production and antioxidant activity in submerged cultures of Inonotus obliquus by lignocellulose decomposition. Journal of Industrial Microbiology & Biotechnology. 2011, 38(2), 291-298. (IF = 3.34)
17. Chen H.; Xu X.*; Zhu Y. Optimization of hydroxyl radical scavenging activity of exopolysaccharides from Inonotus obliquus in submerged fermentation using response surface methodology. Journal of microbiology and biotechnology. 2010, 20(4), 835-43. (IF = 2.35)
Corresponding author articles
18. Dong, F.; Chen, H.*; Malapit, C. A.; Prater, M. B.; Li, M.; Yuan, M.; Lim, K.; Minteer, S. D.* Biphasic bioelectrocatalytic synthesis of chiral β-hydroxy nitriles. Journal of American Chemical Society, 2020, 142 (18), 8374-8382. (IF = 16.38)
19. Dong, F.; Lee, Y. S.; Gaffney, E. M.; Grattieri, M.; Haddadin H.; Minteer, S. D.; Chen, H.* An engineered, non-diazotrophic cyanobacterium and its application in bioelectrochemical nitrogen fixation. Cell Reports Physical Science, 2021, 100444. (IF = 7.83)
Other co-author articles
20. Lim K,; Macazo FC,; Scholes C,; Chen H.; Sumampong K,; Minteer SD.* Elucidating the mechanism behind the bionanomanufacturing of gold nanoparticles using Bacillus subtilis. ACS Applied Bio Materials, 2020, 3(6), 3859-3867. (IF = 3.25)
21. Yuan M,; Abdellaoui S,; Chen H,; Kummer MJ,; Malapit CA,; You C,; Minteer SD.* Selective electroenzymatic oxyfunctionalization by alkane monooxygenase in a biofuel cell. Angewandte Chemie International Edition, 2020, 59, 8969-8973. (IF = 16.82)
22. Patel J.; Cai R.; Milton R.; Chen H.; Minteer SD.* Pyrene‐Based Noncovalent Immobilization of Nitrogenase on Carbon Surfaces. ChemBioChem, 2020, 21, 1729-1732. (IF = 3.46)
23. Grattieri M.; Chen H.; Minteer SD.* Chloroplast biosolar cell and self-powered herbicide monitoring. Chemical Communications. 2020, 56(86), 13161-13164. (IF = 6.06)
24. Huang, R.*; Chen, H.; Upp, D. M.; Lewis, J. C.; Zhang, Y.-H. P. J.* A High-Throughput Method for Directed Evolution of NAD(P)+-Dependent Dehydrogenases for the Reduction of Biomimetic Nicotinamide Analogues. ACS Catalysis, 2019, 9 (12), 11709-11719. (IF = 13.66)
25. Huang R.; Chen H.; Zhou W.; Ma C.; Zhang Y.H.* Engineering a thermostable highly active glucose 6-phosphate dehydrogenase and its application to hydrogen production in vitro. Applied Microbiology and Biotechnology. 2018, 102(7), 3203-3215. (IF = 5.56)
26. Kim J.E.; Kim E.J.; Chen H.; Wu C.H.; Adams M.W.; Zhang Y.H*. Advanced water splitting for green hydrogen gas production through complete oxidation of starch by in vitro metabolic engineering. Metabolic Engineering, 2017, 44, 246-52. (IF = 8.82)
27. Fang B.; Xu H.; Liu Y.; Qi F.; Zhang W.; Chen H.; Wang C.; Wang Y.; Yang W.; Li S.* Mutagenesis and redox partners analysis of the P450 fatty acid decarboxylase OleT JE. Scientific Reports, 2017, 7(1), 1-7. (IF = 4.99)
28. Huang, R., Chen, H., Zhong, C., Kim, J. E., Zhang, Y. H. P. (2016). High-throughput screening of coenzyme preference change of thermophilic 6-phosphogluconate dehydrogenase from NADP+ to NAD+. Scientific Reports, 2016, 32644. (IF = 4.99)
29. Kim J.E.; Huang R.; Chen H.; You C.; Zhang Y.H.* Facile construction of random gene mutagenesis library for directed evolution without the use of restriction enzyme in Escherichia coli. Biotechnology Journal. 2016, 11(9), 1142-50. (IF = 5.72)
30. Zheng X.; Fang B.; Han D.; Yang W.; Qi F.; Chen H.; Li S.* Improving the Secretory Expression of an α-Galactosidase from Aspergillus niger in Pichia pastoris. PloS one. 2016, 22, 11(8), e0161529. (IF = 3.75)
31. Ma, L., Du, L., Chen, H., Sun, Y., Huang, S. H., Zheng, X. L., Li, S.Y. (2015). Reconstitution of the in vitro activity of the cyclosporine-specific P450 hydroxylase from Sebekia benihana and development of a heterologous whole-cell biotrasformation system. Applied and Environmental Microbiology, 2015, 81(18), 6268-6275. (IF = 5.00)
32. Xu X.*, Wu Y, Chen H. Comparative antioxidative characteristics of polysaccharide-enriched extracts from natural sclerotia and cultured mycelia in submerged fermentation of Inonotus obliquus. Food Chemistry. 2011,127(1), 74-79. (IF = 9.23)