Xingwang Zhang obtained his bachelor's degree in Pharmaceutical Engineering at Qilu University of Technology, China in 2010. In 2015, he received his doctoral degree in Medicinal Chemistry by focusing on natural product discovery at Ocean University of China under the supervision of Professor Guoqiang Li. Then he accomplished his postdoctoral training on natural product biosynthesis in Professor Shengying Li's laboratory at Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences. In 2019, he moved State Key Laboratory of Microbial Technology at Shandong University and became a professor in 2024.
Research interests:
Biosynthesis: Focusing on the elucidation of biosynthetic mechanisms and rational modification of natural products.
Biocatalysis: Utilizing AI technology for the discovery and engineering of novel enzymes and pathways.
Major Fundings
1, National Natural Science Foundation of China, 2024 （NSFC面上项目）
2, National Natural Science Foundation of China, 2020 （NSFC青年项目）
3, National Key R&D Program of China, 2023（国家重点研发计划子课题）
4, National Key R&D Program of China, 2021（国家重点研发计划子课题）
5, Taishan Young Scholar of Shandong Province, 2024（山东省泰山学者青年专家）
6, Shandong Key R&D Program, 2023（山东省重大基础研究项目）
Selected Publications:
1) Xingwang Zhang, Fangyuan Cheng, Jiawei Guo, Shanmin Zheng, Xuan Wang, Shengying Li*, Enzymatic synthesis of organoselenium compounds via C‒Se bond formation mediated by sulfur carrier proteins. Nature Synthesis, 2024, 3, 477-487.
2) Xingwang Zhang, Xiaokun Xu, Cai You, Chaofan Yang, Jiawei Guo, Moli Sang, Ce Geng, Fangyuan Cheng, Lei Du, Yuemao Shen, Sheng Wang, Haidong Lan, Fan Yang, Yuezhong Li, Ya-Jie Tang, Youming Zhang, Xiaoying Bian*, Shengying Li*, Wei Zhang*, Biosynthesis of chuangxinmycin featuring a deubiquitinase-like sulfurtransferase, Angewandte Chemie-International Edition, 2021, 60, 24418-24423.
3) Yuwei Xia#; Guoliang Zhu#; Xingwang Zhang#; Shengying Li; Lei Du*; Weiming Zhu*; Biosynthesis of 4-Acyl-5-aminoimidazole Alkaloids Featuring a New Friedel–Crafts Acyltransferase, Journal of the American Chemical Society, 2023, 145(48): 26308-26317.
4) Shanmin Zheng#; Xiuzhi Zhou#; Yuanyuan Jiang; Jiawei Guo; Fangyuan Cheng; Xuan Wang; Hao-Bing Yu; Bo Hu; Chunxiao Meng; Zhengquan Gao*; Shengying Li*; Xingwang Zhang*; Light-driven enzymatic conversion of mevastatin into pravastatin by coupling P450sca-2 with cyanobacterial photosynthetic system, Green Synthesis and Catalysis, 2024, https://doi.org/10.1016/j.gresc.2024.07.001.
5) Shanmin Zheng#, Jiawei Guo#, Fangyuan Cheng, Zhengquan Gao, Chunxiao Meng*,Shengying Li*, and Xingwang Zhang*, Cytochrome P450s in algae: bioactive natural product biosynthesis and light-driven bioproduction, Acta Pharmaceutica Sinica B, 2022, 12(6):2832-2844.
6) Xingwang Zhang, Jiawei Guo, Fangyuan Cheng, Shengying Li*, Cytochrome P450 enzymes in fungal natural product biosynthesis, Natural Product Reports, 2021, 38, 1072-1099. (IF = 10.2)
7) Xingwang Zhang, Shengying Li.*, Expansion of chemical space for natural products by uncommon P450 reactions, Natural Product Reports, 2017, 34(9): 1061.
8) Mingyu Liu, Xingwang Zhang*, Guoqiang Li*，Structural and Biological Insights into the Hot-Spot Marine Natural Products Reported from 2012 to 2021, Chinese Journal of Chemistry, 2022, 40, 186.
9) Fei Guo #, Xingwang Zhang#, Cai You, Chengjie Zhang, Fengwei Li, Nan Li, Yuwei Xia, Mingyu Liu, Zetian Qiu, Xianliang Zheng, Li Ma, Gang Zhang, Lianzhong Luo, Fei Cao, Yingang Feng, Guang-Rong Zhao, Wei Zhang, Shengying Li, Lei Du*, Diversification of phenolic glucosides by two UDP-glucosyltransferases featuring complementary regioselectivity, Microbial Cell Factories, 2022, 21:208-222.
10) Jiawei Guo, Fengwei Li, Fangyuan Cheng, Li Ma, Xiaohui Liu, Pradeepraj Durairaj, Gang Zhang, Dandan Tang, Xiangtian Long, Wei Zhang, Lei Du, Xingwang Zhang*, and Shengying Li, Bacterial biosynthetic P450 enzyme PikCD50N: A potential biocatalyst for the preparation of human drug metabolites. Journal of Organic Chemistry. 2021, 86, 14563−14571.